Oncology Intern:BIO003492

Description

Merck is a global health care leader with a diversified portfolio of prescription medicines, vaccines and consumer health products, as well as animal health products. Today, we are building a new kind of healthcare company - one that is ready to help create a healthier future for all of us.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you'll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.


The intern will use aPKC inhibitor as pharmacologic tools on the established assays to validate aPKC's role in regulating the PAR3/Numb à p120catenin/E-cadherin pathway. If successfully executed, the intern's project may provide new pharmaco-dynamic reporter assays of aPKC function relevant to its role in tumor growth and maintenance and may provide a framework for establishing more clinically translatable and relevant biomarker assays.

Project Overview:

Atypical protein kinase C enzymes function as part of the PAR polarity complex composed of PAR3 and PAR6. The PAR complex participates in cellular polarity events required for normal cell migration and epithelial cell apical-basal polarity. A growing body of evidence suggests that dysregulation of cell polarity may promote epithelial-mesenchymal transition events linked to tumor initiation and metastasis. Recent in vitro biochemical and cell biology experiments employing genetic knock-down have shown a link between aPKC and the proposed tumor suppressor Numb, a membrane-bound substrate of aPKC involved in regulating internalization and trafficking of adhesion receptors (eg integrins and E-cadherin). To date, no studies have employed selective potent aPKC inhibitors to pharmacologically validate its role in Numb regulation. MRL-Boston Oncology has developed selective aPKC small molecule inhibitors well suited for in vitro pharmacology experiments. The intern's project goal will be to pharmacologically validate aPKC's role in regulating Numb-mediated events. Building on literature precedents and employing new assay approaches (eg DuoLink PLA) the intern will help to establish assays that measure aPKC/Par6 à PAR3/Numbà p120catenin/E-cadherin trafficking and protein interactions in relevant tumor cell lines.

This is a 9-11 week, paid internship beginning in June 2012. Housing will be provided to those who meet distance requirement.

Qualifications

Required:

* Currently pursuing a minimum of a BS in Biology or a related discipline.
* Student must be returning to school upon completion of internship.
* Must be available for a period of 9-11 weeks, beginning June 2012.

Preferred:

* GPA of 3.0 or higher

Our employees are the key to our company's success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Merck's benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives.

merck.com/careers to create a profile and your resume for requisition #BIO003492.

Merck is an equal opportunity employer, M/F/D/V - proudly embracing diversity in all of its manifestations.


Primary Location: US-MA-Boston

Job Type
: Intern
Employee Status: Regular
Number of Openings: 1

Bio Prog Team Member Oncology-BIO003481

Description

Merck is a global health care leader with a diversified portfolio of prescription medicines, vaccines and consumer health products, as well as animal health products. Today, we are building a new kind of healthcare company - one that is ready to help create a healthier future for all of us.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you'll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.


As part of the oncology discovery model team, the successful candidate will be responsible for developing both in vivo and in vitro models in support of various drug development programs. You will be involved in translating in vitro findings to relevant in vivo mouse models in an effort to understand the response of Oncology Therapeutics.

Qualifications

Education:

* Required: BS with 5 + years experience
* Preferred: MS with 0 - 2+ years experience

Required Skills and Experience:

* Cell Biochemistry: Analysis of gene and small molecule effects on cells using immunoblot, Immunofluorescence, immunopreciptiation, co-immunoprecipitation, ELISA, Mesoscale, qPCR
* Team work and collaboration: Good oral and written communication skills a must. Capable of working effectively in a team environment. Flexibility in changing project needs which are driven by results.

Preferred Skills and Experience:

* Experience with xenograft, orthotopic mouse models of cancer or the desire to learn these models.
* Cell Biology: 2D and 3D cell culture including soft agar, transfection of cells, generation of stable cells lines, application of siRNA and shRNA, drug treatment of cells in culture, generation of drug resistant cell lines.

Our employees are the key to our company's success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Merck's benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives.

merck.com/careers to create a profile and your resume for requisition # BIO003481.

Merck is an equal opportunity employer, M/F/D/V - proudly embracing diversity in all of its manifestations.


Search Firm Representatives Please Read Carefully:

Merck is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via-email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.

Primary Location: US-MA-Boston
Employee Status: Regular
Number of Openings: 1

Biology Program Team Member - Oncology-BIO003480

Description

Merck is a global health care leader with a diversified portfolio of prescription medicines, vaccines and consumer health products, as well as animal health products. Today, we are building a new kind of healthcare company - one that is ready to help create a healthier future for all of us.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you'll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.


We are seeking an outstanding individual who will support assay/model development for identification and evaluation of patient stratification biomarkers for mono-therapy and combination development programs in our portfolio. In addition, the individual will oversee a number of academic and external collaborations for these lead programs. He/she will partner with clinical monitors other functional group leaders to ensure delivery of high quality pre-clinical data to develop rationale clinical development strategies with clearly defined patient stratification methods. In addition, he/she will be representing MERCK oncology in the external scientific meetings and presentations.

Qualifications

Minimum Education Requirement:

PhD in Molecular, Cell or Cancer Biology, or a related scientic field with 2+ years academic/industry research experience or an MS with 6+ years of relevant industry experience in the development and implementation of pre-clinical models of human cancer and in oncology drug discovery and molecule characterization.

Additional required/preferred Experience:

Experience in in vitro assay development and familiarity with oncology models coupled with a strong background in cancer biology

Experience engaging exploratory collaborations with leading academic groups is required

Familiarity with cancer genomics and RNAi technologies are highly desireable.

Our employees are the key to our company's success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Merck's benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives.

merck.com/careers to create a profile and your resume for requisition # BIO003480.

Merck is an equal opportunity employer, M/F/D/V - proudly embracing diversity in all of its manifestations.


Search Firm Representatives Please Read Carefully:

Merck is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via-email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.

Primary Location: US-MA-Boston
Employee Status: Regular
Number of Openings: 1

Compound Managment Team Member-BIO003477

Description

Merck is a global health care leader with a diversified portfolio of prescription medicines, vaccines and consumer health products, as well as animal health products. Today, we are building a new kind of healthcare company - one that is ready to help create a healthier future for all of us.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you'll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.


This position will support small molecule drug discovery at Merck Research Laboratories Boston in the Department of In Vitro Pharmacology, focusing on Compound Management.

The candidate will support the automated distribution of compounds in solution to assay scientists and provide quality control for compound management hardware within the Assay Operations team. The candidate is expected to design and execute standard operating procedures for operation, maintenance, and quality assurance of compound management laboratory automation, including conventional liquid handlers, robotic arms, acoustic dispensers and other components of an integrated compound management system. The candidate will work closely with other scientists within the department and across functional teams, supporting programs in Oncology and Respiratory & Immunology disease areas by providing critical compound management support.

Qualifications

Requirements: Bachelors degree in Chemistry, Biology, Biomedical Engineering, or other engineering related discipline.

The position requires significant hands-on experience in setting-up, programming, operating, troubleshooting and maintaining both hardware and software associated with automated laboratory equipment.

Experience with platforms such as the Hamilton MICROLAB STAR and ARTEL MVS, and knowledge of HiRes Biosolutions Cellario integration software are a plus.

Strong quantitative skills, and the ability to function and communicate effectively in a highly productive multi-disciplinary environment are a must.

Our employees are the key to our company's success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Merck's benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives.

merck.com/careers to create a profile and your resume for requisition # BIO003477.

Merck is an equal opportunity employer, M/F/D/V - proudly embracing diversity in all of its manifestations.


Search Firm Representatives Please Read Carefully:

Merck is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via-email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.

Primary Location: US-MA-Boston
Employee Status: Regular
Number of Openings: 1

Senior Research Biologist - Proteomics-BIO003453

Description

Merck is a global health care leader with a diversified portfolio of prescription medicines, vaccines and consumer health products, as well as animal health products. Today, we are building a new kind of healthcare company - one that is ready to help create a healthier future for all of us.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you'll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.


The Department of Molecular Biomarkers is seeking a highly motivated individual to join our Biological Mass Spectrometry group. This newly created position requires execution on quantitative proteomic strategies to measure changes in protein expression, and posttranslational modifications in response to stimuli to support the oncology and immunology franchises. Core expertise in mass spectrometry and analytical instrumentations are required as are excellent analysis skills. Preference will be given to those applicants with experience in high resolution mass spectrometry and the use of stable isotopes as internal standards. A Ph.D. in Chemistry/Protein Chemistry or Master's degree with 3 years of experience is required. Understanding of flow cytometry fundamentals and antibody conjugation is a plus. It is expected that the successful candidate will publish independently in first tier peer reviewed journals.

Qualifications

Required Education:

* Must currently possess a PhD in Chemistry/Protein Chemistry or must have a Master's Degree with at least 5 years of research/industry experience.

Required Skills and Experience:

* The position requires advanced and thorough scientific knowledge of mass spectrometry (FT-MS, QQQ, ICP) and proteomic sample preparation (nanoUPLC, immunoprecipitation).
* Must have the ability to plan, recommend and complete research programs of divisional importance.
* Understanding of flow cytometry, antibody conjugation, and peptide sysnthesis is a plus.

Desired Skills and Experience:

* First-author publications are a plus.

Our employees are the key to our company's success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Merck's benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives.

merck.com/careers to create a profile and your resume for requisition # BIO003453.

Merck is an equal opportunity employer, M/F/D/V - proudly embracing diversity in all of its manifestations.


Search Firm Representatives Please Read Carefully:

Merck is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via-email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.

Primary Location: US-MA-Boston
Employee Status: Regular
Number of Openings: 1

Senior Research Scientist - Data Analysis-MOL000277

Description

Merck is a global health care leader with a diversified portfolio of prescription medicines, vaccines and consumer health products, as well as animal health products. Today, we are building a new kind of healthcare company - one that is ready to help create a healthier future for all of us.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you'll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.


Informatics & Analysis Data Analysts provide expert level complex data analysis support to molecular profiling projects across therapeutic areas, specifically for oncology. Development of next generation sequencing technologies demands new skill sets in this job role The skill set will combine expertise in data analysis with deep understanding of genomics and next generation sequencing methods

Qualifications

Education Minimum Requirement:

* Ph D

Required Experience and Skills:

* Demonstrated experience with statistical learning methods, machine learning, and complex data mining techniques and algorithms are required.
* Deep knowledge of genomics, next generation sequencing data and methods of their analysis.
* Excellent track record of high quality publications in peer-reviewed journals.
* Extensive experience in the use of data analysis software (Matlab, R, SAS).
* Strong communication and collaboration skills.

Desired Experience and Skills:

* Minimum of three years of experience in computational biology, biophysics, genomics or other complex data analysis disciplines.
* Knowledge of genomics, next generation sequencing data analysis methods.

Our employees are the key to our company's success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Merck's benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives.

merck.com/careers to create a profile and your resume for requisition # MOL000277.

Merck is an equal opportunity employer, M/F/D/V - proudly embracing diversity in all of its manifestations.


Search Firm Representatives

Please Read Carefully:

Merck is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via-email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.

Primary Location: US-MA-Boston
Employee Status: Regular
Number of Openings: 1

Bioinformatics Team Member-BIO003467

Description

Merck is a global health care leader with a diversified portfolio of prescription medicines, vaccines and consumer health products, as well as animal health products. Today, we are building a new kind of healthcare company - one that is ready to help create a healthier future for all of us.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you'll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.


Merck & Co. Inc. is a global research-driven pharmaceutical company dedicated to putting patients first.
Today, we are building a new kind of healthcare company - one that is ready to help create a healthier future for all of us. Join us and experience our culture first-hand; one of strong ethics & integrity, diversified experiences and a resounding passion for improving human health.

The Informatics and Analysis (I&A) department within Discovery and Pre-Clinical Sciences supports the application of genomic and genetic approaches to biomarker and target discovery to all of MRL therapeutic area franchises. The Research Solutions and Bioinformatics team within I&A works closely with drug program biologists and clinicians to design and analyze data from large scale molecular profiling studies, with an emphasis on biological pathway analysis and interpretation.

Position Description: Highly motivated bioinformatics scientist with a strong background in immunology or oncology. The successful candidate will collaborate closely with pre-clinical and clinical drug programs teams as well as data analysts. This role is at the crucial interface of data analysis and biology and the candidate will be required to master both ends.

The responsibilities of the candidate include but are not limited to:

* Analyzing and integrating large-scale experimental data sets including gene expression, next-generation sequencing and RNAi screens to identify biomarkers of drug response, drug mechanism of action and drug resistance mechanisms.
* Performing biological pathway and network analysis to form hypothesis and collaborating with biologists to suggest further experiments and validate key findings.
* Designing, creating and maintaining databases to host, analyze and share raw and analysis data.
* Devise biomarker strategies that leverage profiling technologies.
* Author sections of biomarker development plans and clinical protocols.

Qualifications

Education Minimum Requirement:

* PhD

Required Experience and Skills:

* Strong bioinformatics skills are required including programming in R/Matlab and Python/Perl.
* Expert knowledge of molecular profiling principles, concepts and theories.
* Experience in the design and bioinformatics analysis of large-scale molecular profiling studies involving transcriptional profiling using microarrays or sequencing technologies.
* Ability to interrogate biological pathways and networks using pathway analysis tools is required.
* Subject matter expertise in immunology or oncology.
* Strong communication and collaboration skills are required, including an ability to communicate complex issues to biologists.
* Demonstrable leadership skills.
* Ability to design, assemble and use databases.

Preferred Experience and Skills:

* Post-doctoral research experience (2-4 years)
* Solid statistical training
* Proven capability to create bioinformatics software tools.

Our employees are the key to our company's success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Merck's benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives.

merck.com/careers to create a profile and your resume for requisition # BIO003467.

Merck is an equal opportunity employer, M/F/D/V - proudly embracing diversity in all of its manifestations.


Search Firm Representatives

Please Read Carefully:

Merck is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via-email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.

Primary Location: US-MA-Boston
Employee Status: Regular
Number of Openings: 1

Discovery Scientist - Safety Assessment-RES000976

Description

Merck is a global health care leader with a diversified portfolio of prescription medicines, vaccines and consumer health products, as well as animal health products. Today, we are building a new kind of healthcare company - one that is ready to help create a healthier future for all of us.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you'll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.


As the Safety Assessment (SA) representative to Merck Research Laboratories discovery research teams at the Boston, MA site, the SA discovery scientist leads the collaboration to define the preclinical SA strategy for programs prior to the approval of First-In-Man enabling GLP toxicity studies. With excellent leadership and collaborative skills, a broad expertise in preclinical safety assessment and an intimate understanding of the science and objectives of the assigned discovery programs, the SA discovery scientist assesses the safety risk using available literature, internal and external data and guides discovery and SA scientists to execute on the appropriate non-GLP SA studies to support selection of therapeutic targets and new molecular entities (NCE) with the highest probability of success for the intended indication. In addition, the SA discovery scientist is part of the scientific team that discovers and implements novel biomarkers and screening strategies. The SA discovery scientist is encouraged to participate in SA functional group activities aligned with their area of scientific expertise.

* Uses literature and data-base resources to understand and define safety risks associated with therapeutic targets.
* Defines the appropriate in silico approaches and in vitro and in vivo studies, including design, dose selection, compound requirements and timing to help innovate and select NCE with the highest probability of success.
* Collaborates with SA and Discovery scientists to assure the appropriate conduct of in silico assessments and in vitro and in vivo studies that support discovery programs.
* Effectively communicates the safety de-risking strategies, study data and conclusion to discovery teams, governance committees and management.
* Collaborates with the discovery and SA scientists to address all scientific issues including assessment of efficacy, metabolism, formulation and purity of drug product and substance.
* Provides consultation and guidance to discovery scientists on complex scientific problems and in general is available for consultation and advice on research approaches.
* Works closely with the SA development compound and therapeutic leaders to assure smooth transition and knowledge transfer for NCE approved for the development and understands safety data from NCE in development to build appropriate derisking strategies to support the innovation of improved back-up molecules.
* Provides due diligence support for licensing efforts of targets and NCE in the discovery space.
* May contribute as study pathologist to exploratory and mechanistic studies supporting discovery teams, if compatible with training and experience.

Qualifications

Education:

* MD, DVM and/or PhD. Degree from an accredited college or university with graduate and/or post-graduate work and/or residency training in Toxicology, Pathology, or related field.

Required:

* 10 or more years experience in Toxicology or related field and 5 or more years of demonstrated experience as pre-clinical SA scientist and team representative in the pharmaceutical industry with an extensive expertise and/or an excellent understanding of regulatory expectations, genetic toxicology, safety pharmacology, reproductive and developmental toxicology and general toxicology and pathology.

Preferred:

* Pharmaceutical experience in leading the pre-clinical safety assessment of small molecule programs for Respiratory, Immunology or Oncology indication in the discovery space.

Our employees are the key to our company's success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Merck's benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives.

merck.com/careers to create a profile and your resume for requisition # RES000976.

Merck is an equal opportunity employer, M/F/D/V - proudly embracing diversity in all of its manifestations.


Search Firm Representatives Please Read Carefully:
Merck is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via-email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.

Primary Location: US-MA-Boston
Employee Status: Regular

Travel
: Yes, 10% of the time
Number of Openings: 1

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